Interplanetary spaceflight or interplanetary travel is the crewed or uncrewed travel between stars and planets, usually within a single planetary system. In practice, spaceflights of this type are confined to travel between the planets of the Solar System. Uncrewed space probes have flown to all the observed planets in the Solar System as well as to dwarf planets Pluto and Ceres, and several asteroids. Orbiters and landers return more information than fly-by missions. Crewed flights have landed on the Moon and have been planned, from time to time, for Mars, Venus and Mercury. While many scientists appreciate the knowledge value that uncrewed flights provide, the value of crewed missions is more controversial. Science fiction writers propose a number of benefits, including the mining of asteroids, access to solar power, and room for colonization in the event of an Earth catastrophe.

A number of techniques have been developed to make interplanetary flights more economical. Advances in computing and theoretical science have already improved some techniques, while new proposals may lead to improvements in speed, fuel economy, and safety. Travel techniques must take into consideration the velocity changes necessary to travel from one body to another in the Solar System. For orbital flights, an additional adjustment must be made to match the orbital speed of the destination body. Other developments are designed to improve rocket launching and propulsion, as well as the use of non-traditional sources of energy. Using extraterrestrial resources for energy, oxygen, and water would reduce costs and improve life support systems.

Any crewed interplanetary flight must include certain design requirements. Life support systems must be capable of supporting human lives for extended periods of time. Preventative measures are needed to reduce exposure to radiation and ensure optimum reliability.